Metabolomics in Metabolic Disease Research

Metabolomics comprehensively characterizes small polar and lipid metabolites, yielding a snapshot of physiological processes that vary according to the pathological state of cells, tissues, and organs. Therefore, metabolomics profiling can help to reveal specific metabolic changes, for example, aberrant levels of amines, amino acids, and lipids, that are known to associate with many metabolic diseases, such as obesity, diabetes, and cardiovascular diseases. Furthermore, metabolomics has a great potential for identifying biomarkers, as well as predictive and risk markers that are associated with disease development and progression, thus, providing an effective strategy for novel therapeutic innovations.

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Introduction

HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to measure small polar metabolites that are involved in a myriad of metabolic diseases, e.g., amino acids, short-chain fatty acids, polyamines in most types of samples, including blood, tissues, and cultured cells.

Quantitation
Over 100 polar metabolites involved in metabolic diseases can be quantified with single- or multi-point calibration.

High resolution
Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.

Description

Examples of samples that can be analyzed at HMT

Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
biomarkers & diagnostic markers relating to disease severity, stress, inflammation
monitor disease progression &/or drug response

Urine, feces, cecal contents
pathogen-induced dysbiosis
detect inflammation-derived changes in metabolic profiles

Cultured cells
changes in energy metabolism in infected cells
assessment of novel therapeutics

Tissues from target organs
interactions between specific tissues & pathogens
monitor metabolic changes for enhanced evaluation of disease progression

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